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Updated: Jan 16, 2026

Tuning Degradation to Achieve Specific and Efficient Protein Depletion
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在Pichia pastoris中辅助诱导目标蛋白质的降解

Leonie Lehmayer1,2, Lukas Bernauer1,2, Anita Emmerstorfer-Augustin3,4,5

  • 1Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, Graz, Austria.

Methods in molecular biology (Clifton, N.J.)
|October 1, 2025
PubMed
概括

辅酶诱导性降解 (AID) 系统能够在Komagataella phaffii中快速降解蛋白质,克服了研究蛋白质功能的传统基因删除方法的局限性.

关键词:
一个辅助的Auxin.有条件的突变物.这是 Degron Degron 的意思.科玛格塔贝拉 (Komagataella phaffii) 是一个有趣的植物.这就是Pichia pastoris.蛋白质耗尽导致蛋白质耗尽.

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