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Updated: Aug 1, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding

Published on: September 15, 2010

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稳定Env TrimerHIV-1 CRF63_02A6在蛋白质和DNA疫苗格式中生产的免疫性

N B Rudometova1, A P Rudometov2, A A Fando2

  • 1State Research Center of Virology and Biotechnology "VECTOR", Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Koltsovo, Novosibirsk region, Russia. nadenkaand100@mail.ru.

Bulletin of experimental biology and medicine
|October 1, 2025
PubMed
概括

这项研究探讨了HIV-1 Env trimers作为疫苗策略. 蛋白质和DNA疫苗,包括主要提升方法,都产生了对HIV-1的中和抗体.

关键词:
CRF63_02A6 一个问题在Env trimers中使用艾滋病病毒-1 艾滋病病毒-1免疫性 免疫性 免疫性

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Inhibitors of Virion Maturation and Assembly01:19

Inhibitors of Virion Maturation and Assembly

As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...