一个共识性免疫失调框架用于败血症和严重疾病
Andrew R Moore1,2,3, Hong Zheng2,3, Ananthakrishnan Ganesan2,3
1Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.
Nature medicine
|October 1, 2025
概括
骨髓和淋巴细胞区的免疫细胞失调与毒症和ARDS等严重疾病的严重程度和死亡率有关. 这一发现表明一种保存机制,并为精准医学提供预后和治疗见解.
科学领域:
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
- 基因组学就是基因组学.
背景情况:
- 关键护理综合征,如败血症,ARDS和创伤,由于疾病异质性,死亡率很高.
- 对于关键疾病的现有免疫内型缺乏清晰度,阻碍了临床应用.
- SUBSPACE联盟的目标是利用转录组数据在重症监护中推进精准医学.
研究的目的:
- 为了评估在多个队伍中发生败血症时免疫内型的重叠.
- 开发细胞类型特定的基因表达特征,用于量化免疫失调.
- 探索免疫失调在严重疾病的预后和治疗影响.
主要方法:
- 分析了来自37个独立的败血症队伍的>7074个转录组样本.
- 开发细胞类型特定的基因表达特征.
- 在ARDS,创伤和烧伤患者中评估免疫失调.
- 随机对照试验数据 (SAVE-MORE,VICTAS,VANISH) 的分析.
主要成果:
- 在所有败血症队伍中,髓质和淋巴细胞失调与疾病严重程度和死亡率相关.
- 在ARDS,创伤和烧伤患者中观察到类似的免疫失调.
- 免疫失调预测了接受anakinra或皮质类固醇的患者的差异性死亡率.
结论:
- 骨髓和淋巴细胞区的免疫失调是危急疾病中保存的机制.
- 一个基于免疫学的新型框架可以量化细胞隔间失调.
- 这一框架对于重症监护中的精准医学具有显著的预后和治疗潜力.
相关概念视频
Immunodeficiency Diseases
2.0K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
2.0K
Factors Affecting the Risk of Infection
13.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.3K
Inflammatory Response
16.0K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.0K
Stress Response System
659
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
659
Pneumonia II: Pathophysiology
2.6K
The pathophysiology of pneumonia involves the following steps:
2.6K
Nursing Clinical Information System
1.2K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.2K


