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基于与衰老相关的基因构建和评估乳腺癌的预后模型

Yaofeng Hu¹, Xinzheng Li¹, LiJun Ma²

¹Department of Breast Surgery, The Second Hospital of Shanxi Medical University, Taiyuan City, 030000, Shanxi Province, China.

Scientific reports

|October 1, 2025

概括

与衰老相关的基因JCHAIN,KRT15和CXCL14是预测乳腺癌预后的关键生物标志物. 过度表达CXCL14抑制癌细胞生长,并激活CD8+T细胞免疫力,提供潜在的治疗策略.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学遗传学是一个

背景情况:

衰老是乳腺癌 (BRCA) 的重要危险因素,但潜在的机制尚未完全理解.
确定可靠的预后生物标志物对于改善BRCA患者的治疗结果至关重要.

研究的目的:

为了确定与BRCA预后相关的与衰老相关的基因.
开发一个风险模型来预测患者的生存率.
研究关键基因,特别是CXCL14在BRCA进展和免疫反应中的功能作用.

主要方法:

达成共识的聚类来分类BRCA亚型.
差异基因表达分析和考克斯回归用于识别预后标志物.
基因组变异分析 (GSVA) 用于途径丰富和免疫细胞透评估.
定量逆转录PCR (qRT-PCR) 用于基因表达的验证.
试验室试验评估CXCL14对癌细胞行为和CD8+T细胞活性的影响.

主要成果:

确定了JCHAIN,KRT15和CXCL14作为关键的预后相关基因,形成了一个预测风险模型.
年龄和瘤阶段被证实是独立的预后因素.
在风险群体中观察到明显的途径丰富和改变的免疫细胞透.
高风险组显示免疫检查点 (LAG3,CD274,CTLA4,PDCD1) 的下调.
过度表达CXCL14抑制了乳腺癌细胞的增殖,入侵和迁移,同时增强了CD8+ T细胞介导的抗瘤免疫力.

结论:

JCHAIN,KRT15和CXCL14作为有价值的与衰老相关的生物标志物,用于预测BRCA预后.
通过抑制癌细胞的攻击性和促进免疫监测,CXCL14表现出抗瘤特性.
这些发现强调了老化,瘤遗传学和免疫微环境在乳腺癌发育和进展中的相互作用.

关键词:

与衰老相关的基因生物信息学是一种生物信息学.乳腺癌是什么? 乳腺癌是什么?预后预后预测预测风险模型风险模型

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