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在怀孕期间使用青 (乙氨基) 和自闭症风险:证据不支持因果关系

Frank Louwen^1,2,3, Eileen Deuster¹, Fionnuala M McAuliffe^2,4

¹Department of Obstetrics and Perinatal Medicine, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

|October 1, 2025

概括

在怀孕期间使用青 (乙氨基) 与自闭症谱系障碍没有因果关系. 强有力的研究表明没有增加风险,使患者和医疗保健提供者放心.

科学领域:

产科和妇科产科和妇科
神经发育障碍神经发育障碍
药理学药理学是指药理学的学科.

背景情况:

最近的担忧是,产前暴露于类醇 (乙氨基) 与自闭症谱系障碍有联系.
这在全球范围内引起了患者和医疗保健提供者的严重焦虑.
现有证据需要进行批判性审查,以解决这些问题.

研究的目的:

批判性地评估有关产前青醇使用与神经发育障碍之间的联系的科学证据.
为了澄清妊娠期间使用 (乙氨基) 的安全性,用于产科实践.
为医疗保健提供者和患者提供基于证据的指导.

主要方法:

审查大规模,基于人群的研究,包括那些与兄弟控制分析.
对观察性研究进行批判性评估,以发现指示和遗传学等混因素.
评估主要国际医疗组织和监管机构的建议.

主要成果:

最大的和最严格的方法研究表明,产前青暴露与神经发育障碍之间没有因果关系.
观察性研究表明,相关性可能会因指示和家族因素而混.
瑞典对248万儿童进行的一项研究发现,在控制家庭混后,风险没有增加.

结论:

产前青 (乙氨基) 暴露与自闭症谱系障碍或其他神经发育障碍没有因果关系.
在怀孕期间未经治疗的孕产妇疼痛和发烧的确定的风险超过了有限的研究中的理论担忧.
降醇仍然是主要卫生组织在怀孕期间临床适用的推止痛药.

关键词:

乙氨基的使用方法自闭症谱系障碍自闭症谱系障碍基于证据的医学是基于证据的医学.神经发育的结果.帕拉西托摩尔是一种可怕的药物.怀孕怀孕怀孕怀孕怀孕

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