在癌症放射治疗中准肠道微生物群和代谢物
Shuling Ma1, Xinpei Li1, Shijie Shang1,2
1Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Clinical and translational medicine
|October 1, 2025
概括
放射治疗可能会损害肠道微生物群,导致损伤. 针对肠道细菌及其代谢物,如短链脂肪酸,可以减少副作用并改善癌症治疗结果.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 放射治疗 (RT) 是一种重要的癌症治疗方法,但经常导致辐射引起的损伤.
- 肠道微生物群在免疫功能和肠道健康中起着至关重要的作用,影响RT的疗效.
- 了解肠道微生物群的影响是缓解RT副作用的关键.
研究的目的:
- 在RT的背景下,审查当前对肠道微生物群及其代谢物的理解.
- 探索针对微生物群的策略,以减少RT毒性并改善患者的预后.
- 突出微生物代谢物的潜力,以提高治疗结果.
主要方法:
- 对肠道微生物群,代谢物和放射治疗研究的文献综述.
- 对微生物群向干预的分析:益生菌,益生菌,饮食和便微生物群移植 (FMT).
- 检查微生物副产品的保护作用,如短链脂肪酸 (SCFA),胆汁酸 (BA) 和托衍生物.
主要成果:
- RT显著改变肠道微生物群的组成,导致肠道损伤和全身毒性.
- 肠道微生物群调节粘膜完整性,免疫反应和RT治疗结果.
- 微生物代谢物 (SCFA,BA,酸衍生物) 显示出对辐射损伤的保护作用,并增强瘤的辐射敏感性.
结论:
- 针对微生物群的干预措施在减少RT相关的毒性和改善患者预后方面表现有前途.
- 微生物代谢物提供潜在的辅助治疗,以提高RT的有效性.
- 这些策略为个性化癌症护理铺平了道路,通过尽量减少副作用并提高RT的有效性.
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