氧化物纳米颗粒的细胞灭绝介导的抗癌活性来自Halophila beccarii的衍生和特征
Jayasheela Sarilla1, Vani Mathakala1, Uma Maheswari Devi Palempalli1
1Department of Applied Microbiology & Biochemistry, Sri Padmavati Mahila Visvavidyalayam, Tirupati-517502, India.
Anti-cancer agents in medicinal chemistry
|October 1, 2025
概括
氧化物纳米颗粒 (Hb-ZnONPs) 是由Halophila beccarii介导的,可以作为抗三阴性乳腺癌的亡剂. 这些纳米粒子在体外有效地诱导了BT-549癌细胞的亡.
科学领域:
- 纳米医学是一种纳米医学.
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 三阴性乳腺癌 (TNBC) 仍然是一个治疗挑战.
- 氧化纳米颗粒 (ZnONPs) 在TNBC中被探索其亡潜力.
- 甲虫中介的ZnONPs (Hb-ZnONPs) 被合成用于潜在的抗癌应用.
研究的目的:
- 为了合成和描述Halophila beccarii介导的氧化纳米粒子 (Hb-ZnONPs).
- 评估Hb-ZnONPs对三阴性乳腺癌细胞的体外抗增殖和亡作用.
主要方法:
- 使用乙酸二酸盐合成Hb-ZnONPs.
- 使用SEM,XRD和稳定性测量对Hb-ZnONPs的表征.
- 在BT-549细胞中通过MTT测定和流细胞计对细胞毒性和亡诱导的评估.
主要成果:
- Hb-ZnONPs的粒子大小为35nm,稳定性很好 (-44.7mV).
- 通过XRD检测证实了六边形的石结构,其元素组成为Zn和O.
- Hb-ZnONPs显著诱导了BT-549细胞的亡,后期亡的剂量依赖性增加.
结论:
- Hb-ZnONPs对三阴性乳腺癌细胞表现出显著的细胞毒性和亡作用.
- Hb-ZnONPs代表了乳腺癌化疗的潜在新疗法策略.
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