综合饮食抗氧化剂指数与美国中年和老年人肉症之间的关联:一个横截面研究
Yongsong Kang1,2, Xiangcheng Tang3, Haifeng Zeng1,2
1Department of Orthopedics, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
Medicine
|October 1, 2025
概括
通过综合性饮食抗氧化剂指数 (CDAI) 测量较高的饮食抗氧化剂摄入量,与老年人患肉症的风险较低有关. 这表明抗氧化剂可能有助于保持肌肉质量和功能随着衰老.
科学领域:
- 营养科学 营养科学
- 老年学是一门学科.
- 流行病学 流行病学
背景情况:
- 随着年龄增长而导致肌肉质量和功能丧失的萨尔科佩尼亚是严重的公共卫生问题.
- 饮食因素,特别是抗氧化剂,越来越多地被认为对减轻与年龄相关的肌肉衰退的潜在作用.
研究的目的:
- 调查综合饮食抗氧化剂指数 (CDAI) 与中老年人和老年人中麻症的患病率之间的联系.
- 为了确定饮食中较高的抗氧化剂摄入量是否能在这个人群中保护人免受肉症的危害.
主要方法:
- 利用了国家健康和营养检查调查 (1999-2018) 中6621名参与者 (年龄≥40岁) 的数据.
- 基于从24小时饮食回忆中摄入6种主要抗氧化剂 (维生素C,E,A,胡卜素,,) 的CDAI计算.
- 定义了使用sarcopenia指数 (尾骨肌肉质量/BMI) 的sarcopenia指数,并确定了截止值.
- 采用多变量逻辑回归来分析CDAI和肉症风险之间的关系,并对潜在的混因素进行调整.
主要成果:
- 在研究队列中,肉类的总体患病率为12.3%.
- 与最低四分之一 (17.1%) 相比,最高CDAI四分之一的参与者具有显著较低的麻症患病率 (8.2%).
- 在CDAI中增加1个单位与萨尔科佩尼亚几率减少7%有关 (OR=0.93,95%CI=0.91-0.95).
- 与最低四分位数相比,最高的CDAI四分位数显示,与最低四分位数 (OR=0.47,95%CI=0.32-0.70) 相比,缩症的几率降低了53%.
- 在各个子组中观察到剂量依赖的风险降低和一致的反向关联,并通过敏感性分析得到证实.
结论:
- 根据CDAI的指标,更高的饮食抗氧化剂摄入量与中年和老年人中 Sarcopenia 的风险降低显著相关.
- 饮食中的抗氧化剂可能在维护肌肉健康和预防肉症方面发挥着至关重要的作用.
- 需要进一步的研究来探索因果机制,并在不同人群中验证这些发现.
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