伊朗的片使用和口腔癌:系统性审查和元分析
Elham Keykha1,2, Mohammad Javad Shabanpour3, Elahe Tahmasebi1,2
1Research Center for Prevention of Oral and Dental Diseases, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Medicine
|October 1, 2025
概括
片使用显著增加了口腔癌的风险近两倍. 在片流行地区,公共卫生举措至关重要,以应对这种不断增长的致癌物质威胁.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 口腔癌是一个重大的全球健康挑战,生存率很低.
- 已确定的危险因素包括酒精和烟草,越来越多的证据表明片使用.
- 本综述探讨了片消费与口腔癌的发展之间的联系.
研究的目的:
- 调查片消费与口腔癌风险之间的关联.
- 综合现有的关于这种关系的观察数据.
主要方法:
- 按照PRISMA的指导方针,在主要数据库 (Web of Science,Embase,PubMed,Scopus) 进行了系统的文献搜索.
- 包括到2025年2月发表的观察性研究.
- 在元分析中使用随机效应模型来计算聚合几率比率,并对异质性,敏感性,出版偏差和研究质量进行评估.
主要成果:
- 分析了来自伊朗的6项观察性研究 (5例对照,1个队列),涉及64412名参与者.
- 片使用与口腔癌的风险增加有显著的相关性 (合并OR=1.85,95%CI:1.24-2.57,P=.002).
- 发现了实质性的异质性 (I2=78.03%),但敏感性分析证实了研究结果的稳定性,并且没有发现出版偏差.
结论:
- 片消费与患口腔癌的风险增加近两倍,支持其被归类为第一组致癌物.
- 公共卫生干预措施,包括教育,戒烟计划和综合查,在片普遍存在的地区至关重要.
- 为了验证这些发现并为针对与片相关的致癌症的多学科策略提供信息,对不同人群进行进一步的全球研究是必不可少的.
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