饮食因素调解了教育程度和慢性牙周炎之间的因果关系:一个双样本的门德尔随机化研究
Linxin Jiang1,2, Simin Li2, Shaohong Huang2
1Department of Prosthodontics, University of Leipzig, Leipzig, Germany.
Medicine
|October 1, 2025
概括
更高的教育程度 (EA) 与较低的慢性牙周炎 (CP) 风险有关. 酒精和水果摄入量调解了这种保护作用,这表明饮食改变可以帮助管理CP.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 教育成就 (EA) 影响健康行为,包括饮食,可能影响慢性牙周炎 (CP).
- 饮食因素在EA和CP之间关系中的调解作用仍然不清楚.
- 了解这些途径对于开发有效的CP管理策略至关重要.
研究的目的:
- 使用孟德尔随机化 (MR) 调查EA对CP的因果作用.
- 确定和量化特定饮食因素在EA-CP协会中的调解作用.
- 为改善CP预防和管理提供基于证据的见解.
主要方法:
- 采用孟德尔的随机化 (MR),并使用来自大型全基因组关联研究 (GWAS) 的总结统计数据.
- 使用反变量加权 (IVW) 作为主要的MR方法,支持MR-Egger,加权中位数和模式方法.
- 进行了敏感性分析,以评估性,异质性和稳定性,包括逆因果关系的施泰格选.
主要成果:
- 更高的EA显示出对CP的显著保护性因果作用 (OR=0.772,P<0.001).
- 酒精消费和水果摄入被确定为重要的调解因素,分别解释了67%和44%的总效果.
- 敏感性分析证实了研究结果的稳定性和可靠性.
结论:
- 基因预测较高的EA因果关系与慢性牙周炎风险降低有关.
- 饮食因素,特别是酒精和水果的消费,在这种保护性关联中起着重要的调解作用.
- 改变饮食习惯,如增加水果摄入量和适度饮酒,可能是CP管理的可行策略.
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