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绝经后妇女的血红蛋白糖化指数和低骨矿物密度之间的关联:对NHANES数据库数据的分析

Yuchen Wang^1,2,3, Weizhong Yu³, Wenke Zhu³

¹Department of Orthopedics, Wujin Hospital Affiliated with Jiangsu University, Changhzou, PR China.

|October 1, 2025

概括

较高的血红蛋白糖化指数 (HGI) 与绝经后妇女低骨矿物质密度 (BMD) 的风险增加有关. 这种关联在较低的饮食抗氧化剂摄入量和老年女性中更为明显.

科学领域:

内分泌学和新陈代谢学
骨健康和骨质疏松症
营养科学营养科学

背景情况:

血球蛋白糖化指数 (HGI) 反映了葡萄糖代谢的变化,可能会影响骨健康.
低骨矿物质密度 (BMD) 是绝经后妇女的一个重大问题,增加骨折风险.
饮食因素,如抗氧化剂摄入量,可能会调节对骨密度的代谢影响.

研究的目的:

调查绝经后妇女中HGI和低BMD之间的关联.
探索饮食抗氧化剂质量评分 (DAQS) 对这种关系的潜在改变作用.
确定更年期后妇女的子组,这些女性最容易患上与HGI相关的低BMD.

主要方法:

来自国家健康和营养检查调查 (2005-2018) 数据的分析.
低BMD的定义是T-score ≤ -1.0.0. 作为一个T-score ≤-1.0.0.
用于评估HGI-BMD关联的后勤回归模型,按DAQS,年龄和骨折史分层.

主要成果:

绝经后女性的HGI≥-0.0835有显著更高的低BMD的几率 (OR=1.47).
在DAQS < 5 (OR = 1.44) 的参与者中,HGI和低BMD之间的关联是显著的.
在65岁以上的妇女 (OR = 1.80) 和没有先前骨折的妇女 (OR = 1.57) 中,观察到低BMD的几率增加.

结论:

升高的HGI与更年期后妇女 BMD 低的风险增加有关.
饮食中摄入的抗氧化剂可能会调节HGI和骨密度之间的关系.
对绝经后妇女骨健康的代谢干预措施的进一步研究是有必要的.

关键词:

骨矿物质密度骨矿物质密度饮食抗氧化剂质量评分饮食抗氧化剂质量评分血红蛋白糖化指数是血红蛋白糖化指数.绝经后的妇女绝经后的妇女危险的风险危险的风险

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