皮下体积变化和与社会功能的相关性在罗马зин治疗下与精神分裂症治疗中克洛扎治疗相比
Ju Gao1, Jinxing Jia1, Qianqian Jiang1,2
1Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou, Jiangsu, 215137, China.
BMC psychiatry
|October 1, 2025
概括
接受原 (CPZ) 治疗的精神分裂症患者表现出比克洛扎 (CLZ) 或对照组更大的皮和皮体积. 在这两组患者中都观察到胸膜体积的减少,胸膜体积可能与社会功能有关.
科学领域:
- 神经成像是一种神经成像.
- 精神病学是一个精神病学.
- 神经解剖学是一个神经解剖学.
背景情况:
- 精神分裂症与结构性大脑变化有关.
- 抗精神病药物,如promazine (CPZ) 和克洛扎宾 (CLZ) 是标准的治疗方法.
- 了解药物对大脑结构的影响至关重要.
研究的目的:
- 在接受CPZ治疗的精神分裂症患者中,比较皮质下大脑体积与CLZ.
- 研究CPZ和CLZ对大脑结构的影响.
- 探索皮下体积与社会功能之间的关系.
主要方法:
- 结构性MRI (3T) 用于测量24名CPZ治疗患者,24名CLZ治疗患者和24名健康对照者的皮层下体积.
- 评估了临床症状 (PANSS) 和社会功能 (SSPI).
- 相关性和预测分析检查了体积和功能的关系.
主要成果:
- 与CLZ组和对照组相比,CPZ组表现出明显更大的和面体积.
- 与对照组相比,在CPZ和CLZ组中,thalamic体积减少了.
- 胸膜体积显示了CPZ组中与社会功能的潜在关联,预测分析表明胸膜体积对SSPI得分的影响.
结论:
- 不同的精神分裂症抗精神病治疗可能与不同的神经解剖学变化有关.
- 这些皮层下体积差异可能反映了药物效应的差异.
- thalamic体积可以作为神经成像标记在精神分裂症的社会功能.
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