治疗耐药性抑郁症,对深度大脑刺激反应不佳,通过心理治疗改善:病例系列
Shuping Fang1, Yingyi Kang2, Jun Zhang3
1Mental Health Center of West China Hospital, Sichuan University, No. 37, Guo Xue Alley, Chengdu, Sichuan Province, 610041, China.
Annals of general psychiatry
|October 1, 2025
概括
对于耐治疗抑郁症 (TRD),认知行为疗法 (CBT) 显著改善了对深度大脑刺激 (DBS) 无反应的患者. 心理治疗可能会提高DBS的结果,这表明TRD管理的综合方法.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
背景情况:
- 深度大脑刺激 (DBS) 是一种公认的治疗治疗耐药性抑郁症 (TRD) 的方法,有效率约为60%.
- 一些患者对DBS表现出有限的反应,突出了对替代或辅助疗法的需要.
研究的目的:
- 报告两例TRD患者对DBS手术反应不佳的病例.
- 研究心理治疗的有效性,特别是认知行为疗法 (CBT),改善DBS后的抑郁症状.
主要方法:
- 案例1:一名患有TRD的女性患者初步对DBS表现出有限的反应,随后进行了系统的CBT,导致症状显著改善.
- 案例2:一名患有TRD的男性患者对DBS有短期反应,但复发;CBT干预导致症状明显改善.
主要成果:
- 两位TRD患者在接受CBT后DBS手术后,抑郁症状显著改善.
- 这些案例表明,CBT可以有效地管理DBS后的残留或新出现的抑郁症状.
结论:
- 这项研究是首次报告TRD患者DBS手术后CBT对TRD患者的影响.
- 将DBS与术后心理治疗 (如CBT) 结合起来,可能会改善整体治疗结果.
- 需要进一步的研究来探索TRD这一综合治疗策略的潜力和机制.
相关概念视频
Electroconvulsive Therapy
902
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
902
Treatment Strategies for Psychological Disorders
729
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
729
Psychosurgery
1.5K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
1.5K
Psychotherapy
482
Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
482
Psychodynamic Therapy
500
Psychodynamic therapies emphasize the exploration of unconscious processes and early childhood experiences as fundamental contributors to psychological difficulties. These therapies, deeply rooted in Freud's psychoanalytic theory, aim to uncover and resolve unconscious conflicts, granting individuals insights that promote emotional and behavioral healing. Contemporary psychodynamic approaches have evolved, integrating a broader range of influences and methodologies while still valuing the...
500
Interpersonal Psychotherapy
314
Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
314


