在双相情绪障碍与延迟睡眠-清醒阶段综合征的双相情绪障碍中,阿里皮普拉单一治疗的病例系列
Tong Li1,2, Ting Yang1, Yuchen Lin1
1Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
BMC psychiatry
|October 1, 2025
概括
阿里皮普拉单一疗法对患有延迟睡眠-清醒阶段 (DSWP) 综合征的双相障碍 (BD) 患者有希望,改善症状和社会功能. 建议对这组患者进行进一步的临床试验.
科学领域:
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 双极性障碍 (BD) 患者患有延迟睡眠-觉醒阶段 (DSWP) 综合征,通常与年龄较小,复发风险增加和社会功能缺陷有关.
- 关于这种并发症的研究有限,缺乏确定的治疗指南.
- 这项研究研究了在患有DSWP综合征的BD患者中Aripiprazole单疗法.
研究的目的:
- 评估在被诊断患有双相情绪障碍和延迟睡眠-觉醒阶段综合征的患者中阿里皮普拉单独治疗的疗效和安全性.
- 评估阿里皮普拉对该患者群体临床症状,睡眠-清醒周期和社会功能的影响.
主要方法:
- 对15名被诊断患有BD和DSWP综合征的患者进行了回顾性图表审查.
- 患者接受了阿里皮普拉 (APZ) 作为单一疗法,治疗持续时间为12至135周.
主要成果:
- 在两周内观察到临床疗效,包括降低临床全球印象-严重性 (CGI-S) 评分和睡眠-清醒周期的进展.
- 在研究结束时,93.3% (14/15) 的参与者实现了临床缓解 (CGI-S < 3),社会功能正常化.
- 最常见的不良事件是可逆的额外金字塔副作用和体重增加.
结论:
- 阿里皮普拉单疗似乎是一种安全有效的治疗双相情感障碍患者经历DSWP综合征.
- 这些发现表明需要通过前性临床试验进行进一步调查,以证实这些结果.
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