病毒性肝炎和抑郁症状之间的关联:国家健康和营养检查调查 (NHANES) 2007-2018年
Guangli Yang1, Siyuan Zhang1, Yanhe Wang1
1Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
BMC public health
|October 1, 2025
概括
病毒性肝炎,包括B型和C型肝炎,与患抑郁症状的可能性更高有关. 这种关联主要是由活跃的病毒性肝炎感染驱动的.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 精神病学是一个精神病学.
- 公共卫生 公共卫生
背景情况:
- 关于病毒性肝炎 (乙型肝炎和C型肝炎) 与抑郁症状之间的联系的证据有限.
- 这项研究调查了病毒性肝炎感染和抑郁症状的患病率之间的联系.
研究的目的:
- 评估病毒性肝炎感染和抑郁症状之间的关系.
- 评估不同病毒性肝炎感染状态对抑郁症状的影响.
主要方法:
- 分析了25635名参与国家健康和营养检查调查 (2007-2018) 的数据.
- 通过血清学测试确定了乙型肝炎 (HBV) 和C型肝炎 (HCV) 感染;使用患者健康问卷-9 (PHQ-9) 测量了抑郁症状.
- 进行了加权的多变量逻辑回归和子组分析,将感染状况分类为从未感染过,以前感染过或活跃感染.
主要成果:
- 病毒性肝炎患者患有抑郁症状的几率较高 (OR=1.72).
- 病毒性肝炎与轻度 (OR=1.46),中度 (OR=1.96) 和重度抑郁 (OR=1.74) 以及更高的PHQ-9分数 (β=1.06) 相关.
- 活跃感染是主要的驱动因素,与抑郁症状有显著的关联 (OR=1.67);没有发现人口统计学或生活方式因素对影响有显著的改变.
结论:
- 病毒性肝炎与抑郁症状独立相关.
- 病毒性肝炎和抑郁症之间的联系主要归因于活跃的感染.
- 建议进行纵向研究以确定因果关系,因为数据的横截面性质.
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