在患有胃肠道癌的患者中, postoperative hypouricemia 和 postoperative 并发症之间的相关性:一个回顾性的嵌套病例对照研究
Kai Shi1,2,3, Hao-Jie Xu1,2,3, Zheng-Lun Lin1,2,3
1Department of Anesthesiology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
BMC cancer
|October 1, 2025
概括
胃肠癌手术后血清尿酸 (sUA) 水平下降,与并发症风险增加相关. 监测术后的SUA可以改善患者的监测和预测并发症.
科学领域:
- 在瘤学瘤学.
- 外科胃肠道外科手术
- 临床化学 临床化学
背景情况:
- 胃肠道癌症手术具有明显的术后并发症风险.
- 了解预测这些并发症的生物标志物对于改善患者的治疗结果至关重要.
- 在这种情况下,手术后的血清尿酸 (sUA) 动态并不成熟.
研究的目的:
- 为了研究在胃肠癌手术期间和之后血清尿酸 (sUA) 水平的变化.
- 确定术后高血压和手术并发症发生之间的关联.
- 评估术后SUA水平对并发症的预测值.
主要方法:
- 708名胃肠道癌症患者 (2018-2020年) 的回顾性嵌套病例对照研究.
- 1:1倾向分数匹配用于将149名并发症患者与149名对照患者进行比较.
- 在手术前 (D0),24小时内 (D1) 和手术后 (1-4天) (D2) 分析的连续sUA测量;按性别特定的值定义的低血. 进行了条件后勤回归和ROC曲线分析.
主要成果:
- 与对照组相比,患有并发症的患者在所有测量时间点 (D0,D1,D2) 呈现出明显较低的sUA水平.
- 在并发症组 (P < 0.001) 的术后第一天和第二天,高血的患病率显著增加 (P < 0.001).
- 手术后的高血压 (D1和D2) 独立地与并发症风险增加有关 (ORs从2.64到11.31). 经过ROC分析,显示了术后sUA水平的预测值 (AUC为D1的0.659,D2的0.699).
结论:
- 手术后血清尿酸 (sUA) 水平的下降与胃肠癌手术后并发症风险增加有显著的相关性.
- 手术后的sUA水平显示出作为并发症发生的预测生物标志物的潜力.
- 监测SUA可能会增强术后监测策略,尽管需要进一步的研究来证实临床效用.
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