与中国成年人的纵向认知变化相关的访问对访问的体重指数变化:一项回顾性队列研究
Shuanghui Guo1, Yuhe Liu2, Xueyu Chen3
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, Beijing, China. 18810673986@163.com.
BMC public health
|October 1, 2025
概括
较高的身体质量指数 (BMI) 变化与老年人认知障碍风险降低有关. 这种关联表明,BMI波动对老年人群中的大脑健康有潜在的保护作用.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 身体质量指数 (BMI) 显著影响整个寿命的认知功能.
- 体重指数的变化,衡量纵向体重指数的变化,越来越被公认为一个关键的健康指标.
- 体重指数变化与认知障碍之间的关系需要进一步研究.
研究的目的:
- 检查BMI变化和认知结果之间的关联.
- 为了比较这些协会在50岁以上和50岁以下的成年人中.
主要方法:
- 分析了来自中国亚最佳健康队列研究 (COCAS) 的1474名参与者.
- 使用诸如变化系数 (CV),标准偏差 (SD),独立于平均值的变化 (VIM) 和平均真实变化 (ARV) 等指标量化BMI变化.
- 认知障碍的评估是使用迷你精神状态检查 (MMSE) 进行的,分析按年龄分层 (> 50 和 ≤ 50 岁) 使用逻辑回归和潜增长曲线建模 (LGCM).
主要成果:
- 在50岁以上的个体中,更高的BMI变化 (特别是CV) 与认知障碍的风险明显降低有关 (OR=0.45,P趋势=0.002).
- 在老年人群中,与SD,VIM和ARV指标发现了类似的反向关联.
- 在50岁或更年轻的参与者中,BMI变化和认知表现之间没有显著的关联.
- 根据LGCM,BMI的轨迹不同:50岁以上的群体下降,50岁以下的群体增加.
结论:
- 增加的BMI变化与老年人认知障碍相反相关.
- 老年人的这种保护作用可能与更健康的减肥模式有关.
- 体重指数的变化可能成为老年人群认知健康的有价值生物标志物.
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