三级淋巴体结构在调节外周器官免疫反应中的作用
Keisuke Taniguchi1, Takahisa Yoshikawa1, Motoko Yanagita2,3
1Department of Nephrology, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawahara-Cho, Sakyo-Ku, Kyoto, 606-8507, Japan.
Inflammation and regeneration
|October 1, 2025
概括
三级淋巴体结构 (TLS) 是非淋巴体组织中的免疫细胞群,在癌症和自身免疫性疾病等疾病中可以具有保护性或有害作用. 了解TLS有助于开发针对各种炎症性疾病的向疗法.
科学领域:
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
- 在瘤学瘤学.
背景情况:
- 三级淋巴体结构 (TLS) 是在慢性炎症期间在非淋巴体组织中发现的有组织的免疫细胞聚合物.
- 它们扮演着双重角色,在感染和癌症中促进宿主防御,但加剧了自身免疫性疾病和移植拒绝.
研究的目的:
- 审查TLS在各种病理条件中的多方面的作用.
- 突出了解TLS异质性的挑战以及新技术在研究和治疗方面的潜力.
主要方法:
- 对癌症,自身免疫性疾病,感染,移植和衰老中的TLS现有文献的综述.
- 讨论用于TLS研究的单细胞奥米克和人工智能方面的进展.
主要成果:
- 根据疾病和器官背景,TLS表现出不同的细胞组成和功能.
- TLSs可以促进抗瘤免疫力,但也可以驱动自身免疫力和慢性炎症.
结论:
- 在各种疾病中,TLS是关键参与者,具有有益和有害的影响.
- 针对TLS形成和成熟提供治疗潜力,但需要考虑系统性影响.
- 新兴技术,如单细胞奥米克和人工智能驱动的诊断,有望为TLS相关疾病提供更深入的见解和新的治疗策略.
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