在复发性/耐药性多发性髓瘤患者中,对全人类BCMA向的CAR T细胞疗法zevorcabtagene autoleucel进行II期研究
Wenming Chen1, Chengcheng Fu2, Baijun Fang3
1Department of Hematology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China. 13910107759@163.com.
Experimental hematology & oncology
|October 1, 2025
概括
泽沃卡巴丁基自杀细胞 (zevor-cel) 在复发性/耐药性多发性骨髓瘤患者中显示出92.2%的客观反应率. 这种CAR T细胞疗法显示出深度和持久的反应,具有可管理的安全性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 细胞疗法细胞疗法
背景情况:
- 泽沃卡巴丁基自细胞 (zevor-cel) 是一项已批准的CAR T细胞疗法,用于中国的复发性/耐药性多发性骨髓瘤 (RRMM).
- 它针对B细胞成熟抗原 (BCMA).
研究的目的:
- 评估zevor-cel在RRMM患者中的疗效和安全性.
- 确定客观响应率 (ORR) 作为主要终点.
主要方法:
- 第二阶段,单臂研究 (LUMMICAR STUDY 1) 在中国23个中心进行.
- 包括18-75岁的RRMM患者,具有可测量的疾病,≥3次先前治疗和ECOG 0-1.
- 被排除的患者先前接受过CAR T细胞或BCMA导向治疗.
主要成果:
- 102名患者接受了泽沃塞尔;中位数年龄为59.5岁.
- ORR为92.2% (95%CI为85.13-96.55),其中68.6%实现了严格的完整反应 (sCR).
- 细胞因子释放综合征发生在90.2% (7%级3/4); 2名患者有1级神经毒性.
结论:
- 在重度预先治疗的RRMM患者中,Zevor-cel诱导了深度和持久的反应.
- 泽沃-塞尔的安全概况是可以管理的.
- 泽沃塞尔为RRMM提供了一个有前途的治疗选择.
相关概念视频
Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K
Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)

