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Updated: Jan 16, 2026

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IRF1通过对NMDAR的GluN1亚单元的O-GlcNAcylation调节来改善突触功能障碍

Xing Fan1, Hao Wang1, Cuiping Guo2

  • 1Department of Biochemistry and Molecular Biology, School of Medicine, Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China.

Alzheimer's research & therapy
|October 1, 2025
PubMed
概括

干扰素调节因子-1 (IRF-1) 缺乏在阿尔茨海默病 (AD) 模型中损害认知功能. 恢复IRF-1通过调节NMDAR功能来改善突触可塑性和记忆.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.在 GluN1 的情况下,GluN1 是在 IRF-1 中,IRF-1 是一个 IRF-1 函数.这是一种O-GlcNAcylation.突触功能障碍 突触功能障碍 突触功能障碍

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