-GPX4轴缓解酸诱导的精子损伤
Huihui Tian1, Jiaying Chen1, Shijie Fan2
1State Key Laboratory of Animal Nutrition and Feeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, No. 2 Yuanmingyuan West Road, Beijing 100193, China.
Journal of agricultural and food chemistry
|October 1, 2025
概括
和谷氨过氧化酶4保护男性生育能力免受过多的酸损害. 这个轴调节代谢物,减少氧化应激,改善精子质量.
科学领域:
- 生殖生物学 生殖生物学
- 营养生物化学 营养生物化学
- 毒理学 毒理学 毒理学
背景情况:
- (Se) 和谷氨过氧化酶4 (GPX4) 对于男性生殖健康至关重要,参与精子生成和防止氧化损伤.
- 阿拉基酸 (AA) 影响男性生育能力,过量摄入会对精子质量产生不良影响.
- Se-GPX4轴减轻AA诱导的丸和精子损伤的确切机制尚未完全理解.
研究的目的:
- 为了研究-GPX4轴如何改善酸诱导的丸和精子损伤.
- 阐明潜在的分子机制,包括基于奥米克的方法.
主要方法:
- 在体内建立一种由酸诱导的精子损伤模型.
- (Se) 补充剂的使用.
- 使用丸特定的GPX4淘汰赛模型.
- 使用氧脂组学和转录组学进行综合分析.
主要成果:
- 补充剂通过调节GPX4表达,在AA诱导损伤模型中显著改善丸和精子质量.
- GPX4淘汰赛加剧了AA诱导的丸和精子损伤.
- Se-GPX4轴干预缓解了氧化应激,细胞亡,性激素障碍和炎症.
- 氧脂组学发现了丸多不和脂肪酸 (PUFA) 代谢物的变化,而转录组学突出了关键受影响的途径.
结论:
- Se-GPX4轴在改善AA诱导的精子损伤方面发挥着至关重要的作用.
- 这种保护作用包括调节PUFA代谢,激活谷氨代谢,减轻氧化应激,亡和炎症.
- 该轴还有助于修复类固醇激素生物合成,从而保持男性生殖功能.
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