对大脑转移的新疗法:一个更新
Marie Porte1, Christophe Massard1,2,3
1Drug Development Department (DITEP), Institut Gustave Roussy, Villejuif.
Current opinion in oncology
|October 1, 2025
概括
针对性药物和免疫检查点抑制剂等全身疗法正在彻底改变大脑转移的治疗方法. 目前正在进行的研究旨在确定最佳的测序与局部疗法,以改善生存结果.
科学领域:
- 神经瘤学神经瘤学
- 癌症治疗方法 癌症治疗方法
- 临床实践指南 临床实践指南
背景情况:
- 大脑转移影响了近20%的癌症患者,由于生存率提高,发病率上升.
- 传统的治疗方法包括手术,全脑放射治疗 (WBRT) 和立体辐射手术 (SRT).
- 最近的进展包括向疗法,免疫检查点抑制剂和抗体药物联合体 (ADC).
研究的目的:
- 审查大脑转移的转变治疗景观.
- 突出新型全身疗法对内疾病控制的影响.
- 强调需要更新临床实践指南的必要性.
主要方法:
- 对脑转移的全身和局部疗法近期进展的审查.
- 针对特定癌症类型的向疗法,免疫疗法和ADC的临床疗效数据的分析.
- 讨论正在进行的研究联合治疗策略的临床试验.
主要成果:
- 系统疗法在非小细胞肺癌,HER2阳性乳腺癌和黑色素瘤中显示出显著的内疗效.
- 无症状或小症状转移可能受益于预先的全身治疗.
- 虽然内控制得到了改善,但生存结果仍然不足于最佳,最佳测序尚未确定.
结论:
- 穿透中枢神经系统 (CNS) 的全身疗法已经改变了大脑转移的管理.
- 进一步的研究和更新的临床实践指南对于优化患者护理至关重要.
相关概念视频
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
01:27Tumor Immunotherapy
1.8K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.8K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:56Treatment Resistant Cancers
3.7K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.7K