加快的衰老沿着精神分裂症的感觉运动关联皮质轴展开:多地点研究
Haonan Pei1, Sisi Jiang1,2, Changyue Hou1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
概括
精神分裂症会加速大脑皮层的衰老,尤其是在疾病早期阶段. 这项研究揭示了区域衰老模式和潜在的神经递质参与,为精神分裂症进展提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 精神分裂症与加速衰老和寿命缩短有关.
- 以前的研究集中在全球大脑年龄差距上,忽视了特定区域的衰老.
- 加速衰老和精神分裂症进展之间的联系仍然不清楚.
研究的目的:
- 为了研究精神分裂症衰老的皮质时空模式.
- 为了检查衰老模式如何随着疾病进展而改变.
- 为了确定精神分裂症患者大脑衰老的区域差异.
主要方法:
- 使用了多站点静止状态功能磁共振成像 (fMRI) 数据.
- 在健康对照组 (n=2353) 和精神分裂症患者 (n=546) 中分析了内在大脑活动波动.
- 开发了规范性衰老模型,并评估了精神分裂症患者的偏差.
主要成果:
- 两组人都在感觉运动关联轴上表现出与年龄相关的皮质变化.
- 精神分裂症表现出更快的皮质衰老,特别是在疾病的早期.
- 精神分裂症的衰老偏差沿着感官运动关联轴持续存在,可能与神经递质系统有关.
结论:
- 确定了沿传感运动关联皮质轴组织的区域衰老轨迹.
- 提供了关于精神分裂症不典型衰老机制的新见解.
- 突出了加速衰老在精神分裂症疾病进展中的作用.
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