案例报告:与TNF-α抑制剂相关的脱素化疾病
Christopher Tuohino1, Trevor Cline2
1Western University of Health Sciences, Pomona, CA, USA.
Journal of investigative medicine high impact case reports
|October 1, 2025
概括
瘤坏死因子-α 抑制剂 (TNF-αi)
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 瘤坏死因子-α抑制剂 (TNF-αi) 是对自身免疫性疾病,如性结肠炎 (UC) 的有效治疗方法.
- 罕见地,TNF-αi与中枢神经系统脱髓化有关,通常是在使用的第一年内.
- 这一案例探讨了与Infliximab相关的延迟出现的脱髓化.
研究的目的:
- 报告一个罕见的中部脱髓化损伤病例,这是因fliximab的次要病例.
- 为了突出TNF-αi治疗的延迟不良影响.
- 强调考虑药物的副作用的重要性,即使在长期使用后也是如此.
主要方法:
- 一个39岁的男性患有UC,长期接受Infliximab治疗的病例报告.
- 麻醉和虚弱的临床表现.
- 磁共振成像 (MRI) 显示皮层增强.
- 排除其他可能的原因.
- 用皮质类固醇和Infliximab悬浮剂进行治疗.
主要成果:
- 一名39岁的男性在使用Infliximab多年后出现了中部脱髓化病变.
- 症状包括左侧四肢麻醉和虚弱.
- 核磁共振扫描显示了右侧皮质增强.
- 停用Infliximab和皮质类固醇治疗导致完全康复.
结论:
- 中枢神经系统脱髓化可能是Infliximab的罕见副作用,即使经过多年的治疗.
- 这种情况发生在此类不良事件的典型时间框架之外.
- 临床医生应该考虑TNF-αi作为神经症状的潜在原因,无论治疗持续时间如何.
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