在非住院患者的肌肉异常与后COVID-19条件
Andrea Tryfonos1,2, Gustav Jörnåker1, Håkan Rundqvist1,3
1Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, Huddinge, Sweden.
Journal of cachexia, sarcopenia and muscle
|October 1, 2025
概括
后COVID疾病 (PCC) 患者表现出骨肌肉退化和再生,纤维尺寸较小,线粒体功能降低. 这些变化可能源于体力活动减少和病毒后效应.
科学领域:
- 肌肉生理学 肌肉生理学
- 后病毒综合征 后病毒综合征
- 骨肌肉病理学 骨肌肉病理学
背景情况:
- 后COVID状况 (PCC) 影响大约10%的个人在SARS-CoV-2感染后,导致持续的症状,如疲劳和肌肉衰弱.
- 这项研究研究了与健康对照人群相比,非住院PCC患者的骨肌肉特征.
研究的目的:
- 评估和比较患有后COVID疾病 (PCC) 患者的骨肌肉形态,病理和分子概况与健康个体.
- 确定PCC肌肉功能障碍背后的潜在机制.
主要方法:
- 分析了28名PCC患者和28名匹配对照的巨横肌肉活检.
- 分析包括形态评估,纤维类型组成,毛细化,肌核数和分子分析 (脂管学,RNA测序).
主要成果:
- 在PCC患者中,角化,小,圆形纤维和胎儿肌肉素表达增加,表明退化和再生.
- 在PCC患者中观察到纤维横截面积和肌核数量显著降低.
- 在PCC患者中发现了减少的毛细化,较低的脂水平和下调的氧化酸化途径.
结论:
- 非住院的PCC患者表现出肌肉变化,暗示退化和再生,可能与减少体力活动有关.
- 肌病性和神经性病毒后影响可能会导致观察到的肌肉变化,包括炎症,纤维化和纤维特征的改变.
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