达夫隆和Centrum通过改善氧化应激,DNA损伤,亡和炎症来减轻大鼠中的万科米辛诱导的毒性
Hanem F El-Gendy1, Soaad Salamah1, Eman Elhusseiny1
1Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.
Frontiers in toxicology
|October 1, 2025
概括
达夫隆 (DF) 和Centrum (CE) 保护大鼠免受万科 (VM) 诱导的损伤. 组合疗法通过减少氧化应激和炎症,显示出优异的保护作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 范科米辛 (VM) 对于治疗耐药性格拉姆阳性细菌感染至关重要.
- 毒性是万科米临床应用的一个显著限制.
研究的目的:
- 调查达夫隆 (DF) 和中心 (CE) 对万胺诱导的毒性产生的保护作用.
- 评估联合DF和CE治疗在减轻脏损伤方面的有效性.
主要方法:
- 雄性Wistar大鼠被分为五组:对照组,VM-only组,VM+DF组,VM+CE组和VM+DF+CE组.
- 治疗包括腹膜内放的万科米辛和口服的达夫隆或Centrum,持续7天.
- 评估包括血清生物化学,氧化应激标志物,DNA损伤测定和组织病理学.
主要成果:
- 范科米辛显著增加了血清肌素,尿素和尿酸,增加了氧化应激 (MDA) 和减少了抗氧化酶 (CAT,SOD).
- VM诱导脏组织学损伤和DNA碎片化.
- 达夫隆和Centrum,特别是在组合中,显著改善了这些效应,减少了损伤和DNA碎片化.
结论:
- 达夫隆和Centrum提供脏保护,防止万科米诱导的毒性.
- 组合疗法通过抗氧化,抗炎和DNA保护机制表现出增强的疗效.
- 这些药物减轻氧化应激,炎症和亡,同时促进抗氧化防御和DNA修复.
关键词:
一个中心,一个中心,一个中心.造成的DNA损伤是DNA损伤.达夫隆 (Daflon) 是一种抗氧化剂是一种抗氧化剂.这是一种炎症性细胞因子.毒性 毒性 毒性氧化应激是一种氧化应激.这就是Vancomycin.更多相关视频
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