狗的口腔 papillary 状细胞癌与淋巴结转移在一只狗
Hidetoshi Ito1, Shiori Ito1, Hirotaka Kondo1
1Hazuki Animal Hospital, 4-17-1, Maruno, Yanaizu, Gifu-shi, Gifu, 501-6115, Japan (H. Ito, S. Ito); Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan (Kondo).
概括
这项研究报告了狗口腔 papillary 状细胞癌转移到淋巴结的第一个病例. 这只狗接受了手术和化疗,长期预后良好,这表明需要对转移进行评估.
科学领域:
- 兽医瘤学 兽医瘤学
- 比较病理学比较病理学
背景情况:
- 狗口腔状状细胞癌 (COPSCC) 是一种罕见的口腔癌.
- 它通常具有较低的转移潜力,并用局部疗法治疗.
研究的目的:
- 报告COPSCC与淋巴结转移的第一个病例.
- 强调在COPSCC病例中评估转移的重要性.
主要方法:
- 一个6个月大的拉布拉多犬的病例报告,有口内质量.
- 诊断成像 (CT扫描) 和组织病理学评估.
- 手术切除质体和受影响的淋巴结,然后进行碳烯化学疗法.
主要成果:
- 组织病理学证实COPSCC转移到下淋巴结.
- 这只狗在手术后的1404天内没有出现局部复发或远程转移.
- 患者在多模式治疗后的长期预后良好.
结论:
- 与以前的理解相反,COPSCC可以转移到淋巴结.
- 对于COPSCC,应考虑准确的转移评估,包括淋巴结活检和化疗.
- 多模式治疗可能会带来有利的长期结果.
相关概念视频
00:49The Tongue and Taste Buds
The surface of the tongue is covered with various small bumps called papillae, which either distribute what has been ingested (filiform papillae) or contain the sensory taste (or gustatory) receptor cells (fungiform, circumvallate, and foliate papillae). Embedded within each taste-related papilla are the taste buds—clusters of 30 to 100 gustatory receptor cells.
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
02:30Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...