早期中性粒细胞与淋巴细胞比率和血小板与淋巴细胞比率下降在持续正气道压力后对2型糖尿病与阻塞性睡眠呼吸暂停的血糖控制的影响
Mengmeng Zhang1, Fuzai Yin1,2
1Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|October 1, 2025
概括
持续正气道压力 (CPAP) 治疗7天内降低中性细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR),预测2型糖尿病患者有阻断性睡眠呼吸暂停的长期血糖控制更好. 这表明NLR和PLR的变化可以表明CPAP治疗的有效性.
科学领域:
- 生物医学科学 生物医学科学
- 临床医学 临床医学
- 睡眠医学 睡眠医学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与2型糖尿病 (T2DM) 和血糖控制不良有关.
- 像中性细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 这样的炎症标志物可能反映T2DM和OSA的全身炎症.
- 持续正气道压力 (CPAP) 是OSA的主要治疗方法,但它对血糖控制和炎症标志物的影响需要进一步阐明.
研究的目的:
- 调查CPAP启动后NLR和PLR早期变化与OSA的T2DM患者的长期血糖控制之间的关系.
- 为了确定NLR和PLR是否可以作为CPAP治疗有效性的预测标记,在这个患者群体中.
主要方法:
- 650名T2DM和OSA患者接受CPAP治疗的回顾性研究.
- 根据长期血糖控制的有效性分类的患者.
- 多因素后勤回归,受限立方线和ROC曲线分析用于评估NLR和PLR变化对血糖控制的影响.
主要成果:
- 在CPAP开始后7天内NLR和PLR的减少是改善长期血糖控制的独立预测因素.
- 减少NLR和PLR显示出与血糖改善的正线性相关性.
- 增加每晚使用CPAP的持续时间,放大了NLR降低对血糖控制的积极影响.
结论:
- 在CPAP治疗后,NLR和PLR的早期降低与OSA的T2DM患者的长期血糖控制的改善显著相关.
- NLR和PLR的变化,特别是与CPAP使用时间结合在一起,可以作为预测CPAP疗效的潜在生物标志物.
- 这些发现为早期干预和优化CPAP治疗策略提供了洞察力,用于OSA的T2DM患者.
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