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Updated: Jan 16, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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Published on: April 9, 2014

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阐明HIV-1核体突变赋予抵抗整合链转移抑制剂的机制

Yuta Hikichi1, Ryan C Burdick2, Sean C Patro3

  • 1Virus-Cell Interaction Section, HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD.

bioRxiv : the preprint server for biology
|October 1, 2025
PubMed
概括

艾滋病毒-1核体 (NC) 的突变加速病毒DNA的整合,降低对整合酶链转移抑制剂 (INSTIs) 的敏感性. 这凸显了需要在治疗失败的艾滋病毒感染者身上进行超越整合酶基因的基因测试.

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