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Updated: Jan 16, 2026

A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers

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DeepEPI:基于CNN变压器的模型,通过预测增强剂-促进剂相互作用来提取TF相互作用

Seyedeh Fatemeh Tabatabaei1, Saeedeh Akbari Roknabadi2, Somayyeh Koohi1

  • 1Department of Computer Engineering, Sharif University of Technology, Tehran, 11155-9517, Iran.

Bioinformatics advances
|October 1, 2025
PubMed
概括

DeepEPI是一个新的深度学习框架,通过分析基因组序列,准确地预测增强器-促进器相互作用 (EPI). 该工具增强了基因表达研究和疾病机制研究,提高了效率和可解释性.

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相关概念视频

Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Co-activators and Co-repressors

Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
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RNA Polymerase II Accessory Proteins

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General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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