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高灵敏度C反应蛋白与动脉硬化随时间变化的纵向变化之间的关联:凯卢安前性队列研究

Weizhe Li¹, Pei Liang², Zhao Han³

¹Department of Emergency Internal Medicine No. I, Handan Central Hospital, Handan, Hebei, 056001, People's Republic of China.

Journal of inflammation research

|October 1, 2025

概括

高灵敏度C反应蛋白 (hs-CRP) 水平显示了剂量与反应的关系,以及随着时间的推移动脉硬度的进展. 这种关联在男性中更为显著,突出显示hs-CRP是动脉样硬化的预测因子.

科学领域:

心血管医学心血管医学
生物标志物生物标志物
流行病学流行病学

背景情况:

动脉硬化是一种动脉硬化,是心血管疾病的重要危险因素.
高灵敏度C反应蛋白 (hs-CRP) 是系统性炎症的标志物.
了解炎症和动脉硬之间的联系对于预测心血管事件至关重要.

研究的目的:

为了研究基线高灵敏性C反应蛋白 (hs-CRP) 水平和动脉硬的纵向进展之间的关系.
为了确定hs-CRP与动脉硬度随时间变化之间是否存在剂量反应关系.
根据性别来探索这种关系中的潜在差异.

主要方法:

一项前性队列研究,涉及Kailuan研究中的25336名参与者.
参与者根据基线hs-CRP水平 (<1 mg/L,1-3 mg/L,>3 mg/L) 被分为三组.
用线性混合效应模型分析了手臂脚脉冲波速率 (baPWV) 的纵向变化.

主要成果:

在平均4.62年的随访期间,baPWV在所有组中都增加.
观察到一种显著的剂量反应关系:较高的hs-CRP水平与较高的baPWV增加率有关.
hs-CRP与baPWV进展之间的关联在男性中更为明显.

结论:

升高的hs-CRP水平与动脉硬的纵向进展有显著的关联.
在hs-CRP和动脉硬度进展之间存在明确的剂量反应关系.
hs-CRP对动脉样硬化的作用在男性中更为明显,这表明性别特定的风险分层.

关键词:

脚-手臂脉冲波速波速波速动脉样硬化动脉样硬化高灵敏度的C反应性蛋白质线性混合效应模型的线性混合效应模型

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