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Updated: Aug 3, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
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类似M1的巨细胞通过P2X4受体调节结直肠癌中的T细胞透

Kun Zhou1, Xintian Zhang1, Yu Liang1

  • 1Shanghai Key Laboratory of Gut Microecology and Associated Major Diseases Research, Digestive Disease Research and Clinical Translation Center, Department of Gastroenterology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

iScience
|October 1, 2025
PubMed
概括

P2X4受体 (P2X4R) 通过引起线粒体功能障碍,在瘤相关的巨细胞 (TAMs) 中驱动M1样极化. 这种重编程增强了抗瘤T细胞的反应,并可能为结直肠癌 (CRC) 提供一种新的治疗策略.

关键词:
癌症 癌症 癌症 癌症细胞生物学 细胞生物学免疫学 免疫学 免疫学微观环境是一个微观环境.

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