一项单一机构的研究评估了用免疫疗法治疗恶性瘤的年轻成年人的生育能力
Jenny D Gong1, Kathryn Coyne2, Matthew Mirsky3
1Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH 44106, United States.
The oncologist
|October 1, 2025
概括
免疫检查点抑制剂 (ICI) 可能不会影响生育能力,因为一些患者在治疗后成功怀孕. 需要进一步的研究来证实这些癌症治疗对生殖健康的长期影响.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 免疫治疗是一种免疫疗法.
背景情况:
- 免疫检查点抑制剂 (ICI) 广泛用于癌症治疗.
- 关于ICI对女性生育能力的长期影响的数据有限.
- 在ICI治疗后,生殖结果和生育服务的利用需要进行调查.
研究的目的:
- 检查ICI治疗的女性癌症患者的生殖结果.
- 在一个单一的高等教育机构详细介绍生育服务经验.
- 评估ICI治疗后怀孕的可能性.
主要方法:
- 对184名接受ICI治疗的女性患者 (18-45岁) 的回顾性分析 (2012年1月至2023年12月).
- 收集关于人口统计,癌症诊断,ICI治疗和生育结果的数据.
- 对生育讨论,转介,生育保护和怀孕的评估.
主要成果:
- 37%的人在ICI前进行了生育讨论;19.6%的人被转介给生殖医学.
- 58.3%的转诊患者接受了生育保存 (卵细胞/胚胎冷保存).
- 3名患者成功怀孕 (1名通过试管婴儿,2名自然),怀孕时间为ICI后12-27个月.
结论:
- 在免疫检查点抑制剂治疗后,成功怀孕是可能的.
- 显著一部分转诊患者使用了生育能力保护的选择.
- 需要进行更大规模的多机构研究,才能充分了解ICI对生育能力的长期影响.
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