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Updated: Jan 16, 2026

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通过SARS-CoV-2蛋白碎片对Aβ1-42聚合的调节

Malinda B Premathilaka1, Ulrich H E Hansmann1

  • 1Department of Chemistry & Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, United States.

Journal of chemical information and modeling
|October 1, 2025
PubMed
概括

SARS-CoV-2 尖蛋白可能通过与粉样蛋白-β 相互作用促进阿尔茨海默病. 这种相互作用将蛋白质转移到聚合,可能会在阿尔茨海默病中恶化粉样蛋白病理.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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