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维生素D补充剂在治疗尿失禁和膀过活的有效性:系统性审查和元分析
Saad Thamer Alshahrani1, Naif Alamri2, Mohammad Dhafer Asiri3
1Urology Department, Armed Forces Hospital Southern Region, Khamis Mushayt.
概括
在本系统性审查中,维生素D补充剂对尿失禁 (UI) 或过活膀 (OAB) 症状没有显著的益处. 需要进一步的研究来探索这些常见疾病的潜在替代疗法.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 尿失禁 (UI) 和膀过活 (OAB) 是普遍存在的下泌尿道症状,影响生活质量.
- 对于UI和OAB的传统治疗通常具有副作用和有限的有效性.
- 维生素D在肌肉功能中的作用及其在膀受体中的存在表明了潜在的治疗价值.
研究的目的:
- 评估维生素D补充剂对管理UI和OAB的有效性.
- 综合现有关于维生素D治疗下泌尿道症状的研究证据.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括十二项研究 (六项RCT,六项队列研究) 进行质量评估.
- 使用标准化平均差异和随机效应模型的风险比率进行统计分析.
主要成果:
- 维生素D和对照组之间的UI症状改善没有显著差异 (SMD = -1.04,p=0.12).
- 维生素D补充对OAB风险没有显著影响 (RR = 1.03,p=0.16) 或UI (RR = 0.88,p=0.59).
- 敏感性分析证实了一致的发现,但排除了一项异常研究.
结论:
- 在UI或OAB患者中,维生素D补充剂与对照组相比没有显著的优势.
- 目前的证据不支持维生素D作为这些疾病的主要干预措施.
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