在也门的第三级护理环境中尿病原体的流行病学和抗菌素耐药性:一项回顾性研究
Faisal Ahmed1, Ennayyat Alhamdani1, Saleh Al-Wageeh1
1Department of Urology, School of Medicine, Ibb University, Ibb.
概括
尿路感染 (UTI) 显示出多抗药 (MDR) 和广泛抗药 (XDR) 病原体的高发病率,特别是大肠杆菌. 以前住院和大肠杆菌感染预测了这些耐药性尿路感染,突出显示了监视和管理的必要性.
科学领域:
- 临床微生物学 临床微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 尿路感染 (UTI) 是一个重大的全球健康挑战,因资源有限的地区抗菌素耐药性 (AMR) 的上升而加剧.
- 这项研究解决了了解人口因素,常见的病原体和这种环境中的尿路感染中耐药性模式的关键需求.
研究的目的:
- 在尿路感染患者中描述人口特征,流行细菌尿病原体和抗菌素耐药性趋势.
- 确定与多药耐药 (MDR) 和广泛耐药 (XDR) 尿路感染相关的临床指标.
主要方法:
- 从2023年1月到2024年9月对216例临床确诊的尿路感染病例进行了回顾性分析.
- 数据包括患者的人口统计,症状,并发症,分离细菌和抗菌素敏感性测试.
- 使用后勤回归模型来确定MDR/XDR感染的预测因素.
主要成果:
- 15-65岁的成年人占大多数病例 (83.3%). 大肠杆菌 (29.6%),金黄色葡萄球菌 (19.0%) 和Pseudomonas aeruginosa (6.0%) 是最常见的分离物.
- 观察到MDR/XDR表型的高患病率 (80.1%),并指出大肠杆菌对西普洛素和氏的显著耐药性 (>60%).
- 预先住院 (aOR=3.15) 和大肠杆菌感染 (aOR=2.41) 被确定为MDR/XDR尿路感染的独立预测因素.
结论:
- 由于MDR/XDR尿病原体的高发病率,需要强有力的抗菌素耐药性监测和管理计划,特别是在资源有限的地区.
- 识别临床预测因素,如先前住院治疗,可以指导实证治疗,改善患者的治疗结果,并制耐药细菌的传播.
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