尿蛋白显示出明显的凝血和补充级联,是急性与慢性狼性炎的基础
Ting Zhang1,2, Jessica Castillo2, Anto Sam Crosslee Louis Sam Titus2
1Division of Rheumatology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
The Journal of clinical investigation
|October 1, 2025
概括
尿蛋白分析显示,作为治疗狼性炎 (LN) 的非侵入性液体活检,它具有前景. 特定的尿蛋白与疾病活性和慢性相关,可能取代侵入性脏活检以监测治疗反应.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
背景情况:
- 评估狼性炎 (LN) 病理通常需要侵入性细胞活检,限制连续监测.
- 开发非侵入性生物标志物对于有效的LN管理至关重要.
研究的目的:
- 为了研究尿蛋白质样本作为狼性炎 (LN) 病理的非侵入性生物标志物.
- 为了将尿蛋白水平与脏活检结果相关联,包括活性和慢性指数.
主要方法:
- 在脏活检时,从LN患者的尿液中对1,317种蛋白质进行基于aptamer的蛋白质性查.
- 统计分析以确定与病理活动指数 (AI) 和慢性指数 (CI) 相对应的蛋白质.
- 在体外研究以阐明补充介导的益菌蛋白信号传递的机制.
主要成果:
- 57尿蛋白与LN病理活动显著相关,包括炎症标志物和细胞激活.
- 尿液中的补充和细胞外基质 (ECM) 蛋白与慢性病理有很强的相关性.
- 在体外,C3a和C5a在细胞和巨细胞中诱导了益菌性ECM蛋白表达.
结论:
- 泌尿蛋白质分析提供了一种潜在的非侵入性方法来评估狼性炎 (LN) 病理活动和慢性.
- 尿蛋白面板可以促进LN患者的连续监测,减少重复脏活检的需要.
- 这种方法可能有助于指导治疗决策和监测LN的治疗疗效.
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