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生物活性物质调节骨髓微环境:机制性见解和治疗潜力

Yizhi Li¹, Luli Ji¹, Jiaze Yu¹

¹State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|October 1, 2025

概括

生物材料精确地调节骨髓微环境 (BME),以恢复骨质平衡. 智能材料模仿生物系统,为骨修复和代谢疾病提供先进的解决方案.

科学领域:

生物材料科学生物材料科学
组织工程是组织工程.
再生医学是一种再生医学.

背景情况:

骨髓微环境 (BME) 对于骨质稳定至关重要,其失调会导致病理性骨质损失.
材料生物学为精确控制BME提供了新的策略.
传统疗法在治疗复杂的骨缺陷和代谢疾病方面存在局限性.

研究的目的:

审查骨髓微环境的生物材料介导调节方面的进展.
突出跨学科整合和智能材料开发用于骨再生.
讨论临床翻译的未来挑战和机遇.

主要方法:

关于生物材料在骨髓微环境调节中的应用的最新文献的综述.
强调仿生设计,功能化策略和智能材料创新.
讨论用于设计抗菌等新生物材料的生成性设计模型.

主要成果:

生物材料可以激活骨质细胞信号来形成骨,并抑制骨质细胞活性进行再吸收.
神经和血管再生与免疫调节机制的整合优化了干细胞的行为.
智能材料模仿生物系统,用于时空控制细胞相互作用和组织修复.

结论:

生物材料介导的BME调节为骨代谢疾病和复杂缺陷提供了有希望的治疗途径.
跨学科方法和智能材料设计是克服当前局限性的关键.
未来的研究应该专注于材料稳定性,个性化适应和临床翻译,以实现跨规模的治疗创新.

关键词:

生物材料是一种生物材料.骨髓微环境骨髓微环境骨基质的骨基质是指骨基质.免疫细胞免疫细胞这是一种神经神经,神经神经神经.干细胞是干细胞的组成部分.血管系统血管系统

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