相关实验视频
Updated: May 11, 2026

07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.8K
乳头甲状腺癌的遗传变化:临床病理相关性和诊断影响
1Department of Pathology, College of Medicine, Taif University, Taif, Saudi Arabia. anam.m@tu.edu.sa.
Folia histochemica et cytobiologica
|October 1, 2025
概括
皮囊性甲状腺癌 (PTC) 中的关键遗传突变,如BRAFV600E和TERT促进子突变,与沙特患者的攻击性特征有关. 了解这些变化有助于为PTC管理提供个性化的风险分层.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
- 遗传学 遗传学 是一个
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的甲状腺癌.
- 关键的基因变异 (BRAFV600E,RAS,RET/PTC,TERT促进体) 影响PTC的攻击性和预后.
- 关于这些突变在中东人口中的流行率和意义的数据有限.
研究的目的:
- 确定沙特阿拉伯PTC队列中BRAFV600E,RAS,RET/PTC和TERT促进子突变的流行率.
- 评估这些遗传变化的临床病理学意义.
- 评估整合下一代测序 (NGS) 和免疫组织化学 (IHC) 在PTC诊断和风险分层方面的实用性.
主要方法:
- 114个PTC样本 (2019-2023) 的回顾性分析.
- 针对BRAF,RAS,RET/PTC融合和TERT促进子突变的有针对性的NGS.
- 针对BRAFV600E和其他标记物的IHC;基因变异和临床病理参数的统计分析.
主要成果:
- BRAFV600E突变 (39.5%) 与较大的瘤大小,甲状腺外延伸和淋巴结转移有关.
- RET/PTC融合 (15.8%) 与多焦点瘤和淋巴血管侵入有关,在年轻患者中更为常见.
- RAS突变 (19.3%) 在卵泡变异中频繁发生;TERT促进器突变 (10.5%) 与年龄较大和晚期相关.
- IHC的结果与分子发现有很强的一致性.
结论:
- BRAFV600E和TERT促进器突变与中东群体中的侵略性PTC特征有关.
- RET/PTC和RAS突变显示出不同的人口和组织学模式.
- 结合NGS和IHC可以提高诊断准确度,并支持个性化的PTC风险分层.
相关概念视频
Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Graves' Disease I: Introduction
Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

