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血清度与绝经后妇女骨折风险之间的关联:一项为期9年的队列研究
Zahra Bahadoran1, Farzad Hadaegh2, Fereidoun Azizi3
1Micronutrient Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, Sahid-Erabi St, Yemen St, Chamran Exp, Tehran, Iran. zahrabahadoran@yahoo.com.
Journal of bone and mineral metabolism
|October 1, 2025
概括
血清 (SZn) 水平较低与绝经后妇女骨折风险较高有关. 保持足够的状况对于这个人口群体的骨健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 骨质疏松症和骨折是绝经后妇女的重大健康问题.
- 血清 (SZn) 度是状况的一个关键指标.
- 在这个人群中,SZn水平与骨折风险之间的关系需要进一步研究.
研究的目的:
- 调查血清 (SZn) 度与绝经后妇女骨折风险之间的关联.
- 探索SZn水平和骨折发生率之间的潜在非线性和剂量反应关系.
主要方法:
- 一组851名绝经后妇女的基线SZn数据 (2009-2011) 被追踪到2018年3月,以检测骨折发生率.
- 限制立方线 (RCS) 模型和考克斯回归被用于评估非线性和剂量反应相关性.
- 多变量考克斯比例危险模型分析了SZn类别的骨折风险:<86,86-135 (参考) 和≥135μg/dL.
主要成果:
- 在8.8年的中位数随访期间,4.3%的女性患有骨折.
- 在SZn和骨折风险之间没有发现显著的非线性关联或剂量反应关系 (分别P=0.176和P=0.448).
- 与基准组 (86-135μg/dL) 相比,有SZn <86μg/dL的绝经后妇女的骨折风险明显增加 (HR=2.29,P=0.044).
结论:
- 血清水平低于最佳水平,表明状况不足,与绝经后妇女骨折风险增加有关.
- 保持足够的含量可能是预防骨折在这一群体中很重要的.
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