在非手术治疗后与骨重矿化相关的临床因素以及对其过程的成像分析
Kiichi Shimabukuro1, Pongsapak Wongratwanich2, Masaru Konishi3
1Department of Oral and Maxillofacial Radiology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima City, Hiroshima, 734-8553, Japan. ksbukuro@hiroshima-u.ac.jp.
Oral radiology
|October 1, 2025
概括
在瘤被摧毁后,大骨的重矿化受患者年龄,瘤类型和辐射剂量的影响. 计算机断层扫描 (CT) 和正电子发射断层扫描/CT (PET/CT) 图像显示了骨愈合过程.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 口腔和牙面部外科手术
背景情况:
- 瘤诱导的骨破坏带来了重大的临床挑战.
- 对于口腔和转移性病变,使用放射治疗和化疗等非手术治疗.
- 了解骨愈合和重矿化对于患者的治疗结果至关重要.
研究的目的:
- 确定与骨重矿化相关的临床因素和过程.
- 分析计算机断层扫描 (CT) 值和正电子发射断层扫描/CT (PET/CT) 成像在瘤诱导的骨损伤.
- 为了澄清非手术瘤治疗后骨愈合的机制.
主要方法:
- 对58名因瘤导致下骨损坏的患者进行了回顾性分析.
- 评估临床因素,治疗方法,以及串行CT和PET/CT成像.
- 在多个时间点测量CT值后处理和计算比率.
主要成果:
- 重矿化发生在23名患者中,其中25名患者没有变化,10名患者经历了渐进的再吸收.
- 年龄,瘤组织学,部位,破坏类型和辐射剂量显著影响了重矿化.
- 在重新矿物化的地点,CT值逐渐增加,与年龄和性别相关的显著差异有所不同.
- PET/CT显示了18F-FDG的积累,表明了与骨重矿化相一致的代谢活性.
结论:
- 骨复矿化是多因素的,受患者特征和治疗的影响.
- CT值的变化和PET/CT代谢活性提供了有关骨愈合过程的见解.
- 年轻患者 (<18岁) 早期的骨愈合显示CT特征与正常骨相似.
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