设计,合成和生物活性研究α-thiocyanato替代的螺旋环四酸衍生物
Yuxuan Zhao1, Xiaoqin Zeng1, Juncheng Xiang2
1Shanghai Key Laboratory of Chemical Biology & School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
Journal of agricultural and food chemistry
|October 1, 2025
概括
研究人员通过添加一个 thiocyanato (SCN) 组开发了新的螺旋环四酸衍生物. 这些化合物具有强大的杀虫剂,杀虫虫剂和除草剂活性,毒性降低,为环保农药提供潜力.
科学领域:
- 农业化学 农业化学
- 有机合成 有机合成
- 农药开发开发 农药开发
背景情况:
- 螺旋环四酸是一种已知的生物活性化合物,用于杀虫剂.
- 持续需要新型杀虫剂分子,提高有效性和减少对环境的影响.
研究的目的:
- 合成新型的螺旋环四酸衍生物,其中包含一个硫酸 (SCN) 组.
- 评估这些新化合物的杀虫剂,杀虫虫剂和除草剂活性.
- 评估毒性概况,特别是斑马鱼的胚胎毒性,以及系统转移性质.
主要方法:
- 通过电友性硫化合成α-SCN替代的四酸衍生物.
- 生物测试以确定对*Tetranychus cinnabarinus*的杀虫活性和对*Aphis craccivora*的杀虫活性.
- 对草原杂草的除草活性查和 *Danio rerio* 的胚胎毒性评估.
- 在植物中进行系统转移研究.
主要成果:
- 与螺旋相比,C16和C20化合物对*Tetranychus cinnabarinus*表现出优越的虫杀伤活性.
- 化合物C1对*Aphis craccivora*表现出类似于螺旋胺的杀虫活性.
- 化合物C16和C28对草原杂草具有显著的除草剂活性.
- 与现有的农药相比,斑马鱼的C1和C16的胚胎毒性降低.
- 生物活性化合物C1和C16表现出与spirotetramat类似的系统转位特性.
结论:
- 将SCN组合理纳入螺旋环四酸结构,可以获得具有高生物活性的衍生物.
- 这些新型化合物表现出有希望的杀虫剂,杀虫剂和除草剂特性,具有有利的毒性概况.
- 开发的SCN替代的螺旋环四酸为创新环保农药替代品提供了宝贵的途径.
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