在非细分性 Vitiligo 中分泌的 Frizzled 相关蛋白 5:临床和免疫组织化学研究
Wafaa Ahmed Shehata1, Mohamed A Shoeib1, Eman Samy Mahmoud Abdou Flefal2
1Dermatology, Andrology & STDs Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.
The American Journal of dermatopathology
|October 1, 2025
概括
在非细分性白风皮肤中,分泌的纹相关蛋白5 (SFRP5) 表达升高. 这一发现表明SFRP5在白风病变发生过程中发挥作用,并且可能是未来的治疗点.
科学领域:
- 皮肤病学 皮肤病学
- 免疫组织化学 免疫组织化学
- 分子生物学分子生物学
背景情况:
- Vitiligo 是一种色素丧失障碍,在全球范围内影响0.5%-1%.
- Wnt信号传递对于黑色素细胞发育至关重要.
- 分泌的纹相关蛋白5 (SFRP5) 抑制Wnt信号,是潜在的白风目标.
研究的目的:
- 研究非细分性白风患者与健康对照者的SFRP5免疫组织化学表达.
- 与临床病理学信息相关联SFRP5表达.
主要方法:
- 包括48名参与者 (24名白风患者,24名对照).
- 收集完整的病史并进行皮肤检查.
- 使用疾病活动和区域评分指数得分白风.
- 在皮肤活检上对SFRP5进行免疫组织化学染色 (损伤性,周周性,对照性).
主要成果:
- 与对照人群相比,SFRP5表达,H评分和IRS在病变性和周围病变性白风皮肤中显著增加 (P < 0.001).
- 在表皮/皮肤SFRP5表达和阳性细胞百分比,H-Score和IRS (P<0.001) 之间发现了显著的相关性.
- 皮肤SFRP5与白风疾病活动评分相关 (P = 0.051).
结论:
- 在损伤性/损伤性皮肤中SFRP5升高表明在非细分性白风的发病过程中发挥了作用.
- SFRP5可能成为有前途的未来治疗点.
- 在白风患者中,SFRP5显示出潜在的预后作用.
相关概念视频
Papillary Dermis
5.4K
Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...
5.4K
Reticular Dermis
4.4K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
4.4K
Changes in Skin Color: Clinical Perspectives
3.3K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.3K
Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
Folliculogenesis
2.1K
Folliculogenesis is the development of ovarian follicles, the specialized structures within the ovarian cortex where oogenesis, or egg development, occurs. This process is essential for female reproductive health and begins during fetal development when primordial follicles are formed. Each primordial follicle comprises a primary oocyte in the center, surrounded by a single layer of squamous pre-granulosa cells. These follicles remain dormant in late prophase I of meiosis until triggered by...
2.1K
Role of Skin in Vitamin D Synthesis
7.6K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.6K


