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在SARS-CoV-2的分子基础上校对酶介导的对remdesivir的耐药性

Yang Yang1, Yu Li1, Scott T Becker1

  • 1Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011.

Proceedings of the National Academy of Sciences of the United States of America
|October 1, 2025
PubMed
概括

SARS-CoV-2 通过使用其校对外核糖酶 (ExoN) 来去除抗病毒药物来抵抗remdesivir. 这种ExoN介导的抗性机制在所有冠状病毒中保留,影响未来的抗病毒开发.

关键词:
冠状病毒冠状病毒病毒低温电磁波冷却器 (Cryo-EM) 是一个非常好的方法.药物耐药性 耐药性 药物耐药性校对阅读 校对阅读雷梅西维尔 (remdesivir) 是一种药物.

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