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白质损伤推动了质母细胞瘤的早期进展

Keon Woo Kim1, Hyun Jin Choi1, Jeong Ho Lee1,2

  • 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

Cancer research
|October 1, 2025
PubMed
概括

早期的大脑瘤细胞会损害白质,导致瓦勒里亚变性. 这种损伤加速了质母细胞瘤 (GBM) 的进展,揭示了大脑癌症的新治疗点.

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Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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