发酵生长减少了黄金葡萄球菌的铁需求
Jeffrey M Boyd1, Gustavo Rios-Delgado1, Karla Esquilín-Lebrón1
1Department of Biochemistry and Microbiology, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.
Journal of inorganic biochemistry
|October 1, 2025
概括
金黄色葡萄球菌通过从呼吸转移到发酵来适应铁限制. 这种代谢开关减少了对铁的依赖,在铁稀缺时,有助于在感染期间的生存.
科学领域:
- 微生物学 微生物学
- 细菌病原体的产生
- 代谢适应 代谢适应
背景情况:
- 铁 (Fe) 对黄金葡萄球菌的生存和毒性至关重要.
- 宿主免疫力限制了铁的可用性,以对抗细菌感染.
- 黄金菌利用铁的吸收调节器 (Fur) 和Fpa来控制铁含量.
研究的目的:
- 为了研究S. aureus在铁限制条件下的代谢适应.
- 了解毛皮无活化在铁有限生长中的作用.
- 阐明S. aureus在感染期间应对稀缺铁的机制.
主要方法:
- 进行了转录组和代谢组分析.
- 进行了基因失活研究,特别是毛皮失活.
- 在缺乏铁的条件下监测细菌生长.
主要成果:
- 皮毛无活化是铁限制期间生长所必需的,独立于高亲和度铁吸收系统.
- 铁的限制或毛皮的不活化导致呼吸减弱和发酵增加.
- 发酵性生长允许金黄色保持氧化还原平衡,减少对铁的依赖.
结论:
- 黄金菌转向发酵,以在感染期间遇到的铁有限条件下生存.
- 这种新陈代谢适应减少了对铁的依赖,促进了细菌的生存和病变发生.
- 了解这些适应性策略可以了解宿主-病原体相互作用.
关键词:
Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa Fpa皮肤皮肤皮肤皮肤皮肤铁铁铁是什么意思 铁铁铁黄金葡萄球菌黄金葡萄球菌硫的存在是因为硫.这就是YlaNN.更多相关视频
相关概念视频
Oxygen Requirements and Growth Patterns
1.2K
Microorganisms exhibit diverse oxygen requirements and growth patterns driven by their metabolic strategies and environmental adaptations. Oxygen, while essential for many organisms, can also be toxic under certain conditions, shaping how microorganisms grow and survive.Oxygen Requirements of MicroorganismsMicroorganisms are classified based on their ability to use or tolerate oxygen:● Obligate aerobes like Mycobacterium tuberculosis need oxygen for energy production, as it serves as the...
1.2K
Microbial Fermentation
1.3K
Fermentation is a crucial anaerobic metabolic process that enables microbes to derive energy from sugar without relying on oxygen or an electron transport chain. This process is fundamental to various biological and industrial applications and is classified based on the metabolic products generated.Role of Pyruvate in FermentationPyruvate and its derivatives serve as key electron acceptors in fermentative pathways. The oxidation of NADH to regenerate NAD+ is essential for the continuation of...
1.3K
Antimicrobial Proteins
13.0K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
13.0K
Fermentation
128.7K
Most eukaryotic organisms require oxygen to survive and function adequately. Such organisms produce large amounts of energy during aerobic respiration by metabolizing glucose and oxygen into carbon dioxide and water. However, most eukaryotes can generate some energy in the absence of oxygen by anaerobic metabolism.
Fermentation is a type of metabolic process that occurs in the absence of oxygen, where organic molecules such as glucose are broken down to produce energy. During this process, the...
Fermentation is a type of metabolic process that occurs in the absence of oxygen, where organic molecules such as glucose are broken down to produce energy. During this process, the...
128.7K
Microbial Nutrition
1.1K
Organisms exhibit remarkable metabolic diversity, categorized based on how they acquire energy and carbon. These strategies enable survival in various ecological niches and are essential for maintaining energy flow and nutrient cycling within ecosystems.Energy and Carbon SourcesOrganisms are classified as phototrophs or chemotrophs based on energy acquisition. Phototrophs use light as their energy source, while chemotrophs rely on oxidizing chemical compounds. Further differentiation arises...
1.1K
Microbial Growth Media
1.3K
Microbial growth media are essential tools in microbiology, providing the nutrients and conditions necessary to cultivate and study microorganisms. These media are categorized by their composition, consistency, and functional roles, enabling researchers to investigate microbial physiology, behavior, and interactions.Types and Consistencies of Growth MediaGrowth media can be solid, liquid, or semisolid. Solid media, often agar-based, allow visible colony growth for isolation and enumeration.
1.3K


