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纳灵宁通过减少氧化应激,炎症和亡来减轻5-甲诱导的毒性
Fatih Mehmet Gür1, Sedat Bilgiç2, İbrahim Aktaş3
1Department of Histology & Embryology, Faculty of Medicine, Niğde Ömer Halisdemir University, Turkey.
纳灵宁 (NAR) 能防止5-甲 (5-FU) 诱导的损伤. NAR具有抗氧化,抗炎和抗丧性质,可以减轻5-FU的作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 5-甲 (5-FU) 是一种广泛使用的化疗剂,已知具有毒性作用.
- 药物诱导的损伤是一个重大的临床问题,需要采取保护策略.
- 宁素 (NAR) 是一种天然的黄胺,具有抗氧化和抗炎性质.
研究的目的:
- 调查纳灵 (NAR) 对5-甲 (5-FU) 诱导的毒性产生的保护作用.
- 阐明NAR脏保护作用的基本机制.
主要方法:
- 大鼠被分为四组:对照组,NAR,5-FU和NAR + 5-FU.
- 脏组织和血液使用生物化学试验,免疫组织化学,TUNEL试验和组织病理学分析.
- 评估了氧化应激,炎症,亡和功能的主要标志物.
主要成果:
- 5-FU的使用显著增加了MDA,BUN,TNF-α,caspase-3水平,以及脏组织中的亡.
- 5-FU诱导严重的组织病理损伤,包括炎症,出血和管道损伤.
- NAR治疗显著减轻了5-FU诱导的氧化应激,炎症,亡和组织病理变化.
结论:
- 纳灵宁 (NAR) 有效地保护对5-甲 (5-FU) 诱导的毒性.
- NAR的保护作用归因于其抗氧化,抗炎和抗丧性质.
- 治疗机制包括Nrf2上调和NF-κB下调.
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