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设计,合成和生物评估与死亡相关的蛋白激酶1 PROTACs

Xueyin Wu1, Ruomeng Li2, Wujin Tian1

  • 1Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University (FMU), Fuzhou, Fujian 350122, China.

Bioorganic chemistry
|October 1, 2025
PubMed
概括

开发了针对死亡相关蛋白激酶1 (DAPK1) 的第一类PROTAC. 化合物CP1有效降解DAPK1,显示出治疗神经退行性疾病和神经元细胞死亡的潜力.

关键词:
与死亡相关的蛋白质激酶1死亡相关.降解降解是一种降解.神经元细胞死亡的神经元细胞死亡这就是PROTAC.

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