胎盘微塑料污染及其对新生儿甲状腺功能的影响
Xuan Zhang1, Li Li2, Yue Zhang2
1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.
Ecotoxicology and environmental safety
|October 1, 2025
概括
暴露于胎盘微塑料 (MPs) 与新生儿甲状腺激素水平降低有关. 这项研究发现,MPs,包括PVC,PP和PBS,在婴儿中显著降低了自由甲状腺素 (T4) 和甲状腺刺激激素 (TSH).
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 微塑料 (MP) 在人体组织中越来越多地被检测到,包括胎盘.
- 甲状腺激素对于胎儿的生长和发育至关重要.
- MPs通过甲状腺功能障碍对新生儿健康的潜在风险越来越令人担忧.
研究的目的:
- 调查胎盘微塑料水平与新生儿甲状腺激素概况之间的关联.
- 评估特定微塑料类型 (PVC,PP,PBS) 对胎儿甲状腺激素度的影响.
主要方法:
- 一项对1250对母婴对 (2022-2024) 的队列研究.
- 测量带血中的甲状腺激素 (自由甲状腺素[T4],自由三甲状腺素[T3],甲状腺刺激激素[TSH]).
- 对胎盘微塑料 (PVC,PP,PBS) 的量化和使用多变量回归模型 (MLR),量子式g计算 (g-comp) 和贝叶斯内核机器回归 (BKMR) 的分析.
主要成果:
- 新生儿T4和TSH水平的显著降低与暴露在PVC,PP和PBS微塑料中有关.
- 在PVC和PP暴露时观察到T4/T3比率的下降.
- 聚烯 (PP) 是唯一一种与T3水平增加相关的微塑料类型.
- 确定了剂量反应关系,较高的MP暴露与较低的T4和T4/T3比率相关.
结论:
- 胎盘微塑性暴露与新生儿的甲状腺激素简介变化有关.
- 关键发现表明T4和T4/T3比率下降,这表明甲状腺功能可能受到干扰.
- 该研究强调需要进一步研究产前MP暴露对长期健康的影响.
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