对于中风风险评估的心房动患者的三维左心房应变分析:具有和没有中风病史的患者之间的比较
Han Yu1, Hujin Xie1, Zidun Wang2
1School of Mechanical, Medical and Process Engineering, Queensland University of Technology, Brisbane, QLD 4000, Australia; Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, QLD 4000, Australia.
Journal of biomechanics
|October 1, 2025
概括
在心房动 (AF) 患者中,左心房 (LA) 应变的减少可能表明中风风险. 三维 (3D) LA菌株分析,特别是在后壁,显示出确定高风险个体的希望.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 生物医学工程 生物医学工程
背景情况:
- 心房动 (AF) 患者面临高心血管血栓性中风风险.
- 减少左心房 (LA) 变形,与纵向应变一样,是潜在的中风风险指标.
- 目前的方法可能无法完全捕捉与中风风险相关的LA功能障碍.
研究的目的:
- 评估三维 (3D) LA 全球和局部菌株使用4D CT血管学在持久性AF患者.
- 为了比较患有和没有心血管血栓性中风病史的患者的LA菌株.
- 评估三维LA菌株参数对确定中风风险的有用性.
主要方法:
- 包括22名患有持续性AF的患者 (11名先前患有心血管血栓性中风).
- 使用一种新的网格规则化子体积跟踪方法计算LA菌株.
- 在8个LA地区分析LA形态,CHADS-VASC2得分和3D全球/本地菌株.
主要成果:
- 患有心血管栓塞性中风的患者表现出明显较低的全球LA菌株 (0.090对0.101,p=0.006).
- 在中风患者的屋顶 (0.087比0.106,p=0.030),后部 (0.055比0.072,p<0.001) 和地板 (0.083比0.097,p=0.022) 区域观察到下部LA菌株.
- 逻辑回归显示,LA后向量精度为0.8958,用于识别先前的中风事件.
结论:
- 3D LA 全球和局部应变测量对于持续性AF非常有价值.
- 关节后壁的拉伸是一个特别强大的指标,用于识别患有心血管栓塞性中风高风险的患者.
- 这种技术为完善AF患者中风风险分层提供了一个有前途的工具.
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